Doctoral Researcher in Computational Cancer Biology (m/w/d)

The Georg-Speyer-Haus in Frankfurt am Main, Institute for Tumor Biology and
Experimental Therapy, is an academic non-profit research institute supported by
the Federal Ministry of Health and the Ministry for Sciences and Arts of the
State of Hessen. The institute is dedicated to basic and translational cancer
research in the context of the tumor microenvironment and closely cooperates
with the Goethe University Frankfurt and the Frankfurt University Hospital. It
provides access to a broad variety of core facilities and an excellent
scientific environment.

We are seeking a

Doctoral Researcher in Computational Cancer Biology (m/f/d)

to join the lab of Dr. Michael Tyler at the Georg-Speyer-Haus Institute for
Tumor Biology and Experimental Therapy, applying data Integration approaches to
understand the changes in cellular heterogeneity during cancer progression.

Project description

Our lab aims to characterise the changes in cell states and interactions
between healthy tissue, primary tumours and advanced cancer stages. Our work is
centred around the curation and integration of many published genomic datasets,
with a focus on single-cell RNA-seq (scRNAseq) and spatial transcriptomics
data. By conducting large-scale comparisons of transcriptomic and spatial
profiles across many patients, cancer types and disease stages, we aim to
uncover robust signatures of cancer progression that reveal general principles
of tumour development and suggest new therapeutic opportunities.

This work involves analysis of large datasets with statistical computing
tools, using a high-performance computing cluster. Key tasks include curating
datasets; developing computational methods for detection and comparison of cell
states and interactions; and interpreting results to yield clinically relevant
insights. Specific challenges include efficient handling of large volumes of
data, and controlling for technical artefacts while preserving biological
effects.

Read more about the research of Michael Tyler on our website

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Requirements

* Masters degree in life sciences or a numerical discipline.
* A strong interest in cancer research and computational biology.
* High motivation, curiosity, proactivity and creativity.
* Willingness to engage in a collaborative environment.
* Proficiency in English.
We offer

* Excellent mentorship and development of a scientific profile.
* An outstanding international cancer research environment.
* A collaborative and friendly atmosphere.
* Participation in further training programs.
* A salary in accordance with the agreement for public service of the state
of Hessen (E13, 65 %), including social benefits, available for 3 years
with the option for extension.
Interested?

Applications should be submitted electronically to
bewerbung@georg-speyer-haus.de

as a single PDF containing a cover letter, CV, publication list, the names and
contact details of two referees, and degree certificates.

For further information, please contact Dr. Michael Tyler (
m.tyler@georg-speyer-haus.de

).

Our international working environment promotes equal opportunities for all
staff regardless of gender, age, cultural background, nationality or
impairments under criteria of scientific excellence. Applications from women
are explicitly welcome. Disabled individuals will be preferred in case of equal
qualification.

For Information about the Georg-Speyer-Haus please visit our homepage

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Georg-Speyer-Haus
Paul-Ehrlich-Str. 42-44 | 60596 Frankfurt/Main